Summary ketamine powder is a rapidacting anesthetic that can produce anesthesia while maintaining. What should i tell my health care provider before i take this medicine. Ketamine hydrochloride injection, usp msds msdsdigital. The pharmacokinetics of ketamine hcl in the cat was described by a 2compartment open model. Ketamine hydrochloridexylazine hydrochloride solution.
Male and female rats were treated with 10 mgkg ketamine iv 0. Sigmaaldrich material safety data sheet date printed. Ketamine hcl ciii ketamine hydrochloride injection, usp. Ketamine hydrochloride ketamine hcl side effects, images. Ketamine hydrochloride injection, usp is a rapidacting, nonnarcotic, nonbarbiturate agent for anesthetic use in cats and for restraint in subhuman primates. Identification of the substancemixture and of the companyundertaking. To report suspected adverse reactions, to obtain a material safety data sheet or for technical assistance, call 18889638471.
Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 20chlorophenyl2 methylamino cyclohexanone hydrochloride. Ketamine is an anesthetic, used to induce a loss of consciousness and relieve pain. Ketamine is an anesthetic agent which is known to cause double vision, motor incoordination, delirium, hallucinations, irrational behavior, and temporary elevation of blood pressure and pulse rate. Ketamine, a noncompetitive nmda receptor blocker, has been used extensively off label as a pediatric anesthetic for surgical procedures in infants and toddlers.
Oct 12, 2017 ketamine is an anesthetic, used to induce a loss of consciousness and relieve pain. O cas number 6108050 alternate cas number not applicable molecular weight 288. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of nmethyl daspartate receptors. The crystal structure of the title compound systematic name. Ketamine is used in patients 16 years of age or older for the induction of anesthesia or. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. The remaining components are nonhazardous andor present at amounts below reportable limits. The effects of a ketamine high usually last an hour but they can last for 46 hours, and 2448 hours are generally required before the user will feel completely normal again. Prescribing information product monograph ketalar ketamine. Apr 02, 2019 ketamine hydrochloride patient information including how should i take what should i discuss with my health care provider before receiving ketamine. It is chemically designated dl 2ochlorophenyl2methylamino cyclohexanone hydrochloride and is supplied as a slightly acid ph 3. Skin protection if solution contact with unprotected skin is likely, use of impervious gloves is a prudent practice.
Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated 2ochlorophenyl2methylamino cyclohexanone hydrochloride. Description ketaset ketamine hydrochloride injection, usp is a rapidacting, nonnarcotic, nonbarbiturate agent for anesthetic. It was extensively used for surgical anesthesia in the vietnam war due to its safety. Ketamine hydrochloride ciii, usp is an anesthetic medication.
Ketamine is a medication mainly used for starting and maintaining anesthesia. Because of the involvement of spinal nmda receptors in the process of central. Ketamine hydrochloride safety data sheet section 2. Ketamine hydrochloride injection, usp for animal use. Carbon oxides, nitrogen oxides n ox, hydrogen chloride gas 5. Description ketaset ketamine hydrochloride injection, usp is a rapidacting, nonnarcotic, nonbarbiturate agent for anesthetic use in cats and. This is a solution of ketamine hydrochloride, an nmda receptor antagonist, and xylazine hydrochloride, an. Pregnant rabbits were treated intramuscularly with 20 mgkg ketamine 0. Ketamine can also produce a transient respiratory depression therefore its use requires regular monitoring of vital signs 1. Eye protection eye protection is not required during expected product use conditions but may be warranted should a splash potential exist. Ketamine was discovered in 1962, first tested in humans in 1964, and approved for use in the united states in 1970.
It is commonly abused for its hallucinogenic and dissociative effects and, controversially, it. Effects typically begin within five minutes when given by injection. All spectrum chemical manufactured usp grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected. Ketaved ketamine hcl 100 mgml is indicated for use in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. One monument square, suite 400 portland, me 04101 18666830660. When ketamine is used on an outpatient basis, the patient should not be released until recovery from anesthesia is completed and then should be accompanied by a responsible adult. Hospira, formerly the hospital products division of abbott laboratories, was. Ketamine is an nmda receptor antagonist, but it may also have other actions. Ketamine may relieve tension and anxiety, is purported to be a sexual stimulant, and intensifies colors and sounds. Mixture name product identifier % classification ghsus ketamine hydrochloride cas no 1867669 proprietary acute tox. In the title compound, the cyclohexanone ring adopts a chair. Zetamine ketamine hydrochloride injection is a rapidacting, nonnarcotic, nonbarbiturate agent for anesthetic use in cats and for restraint in subhuman primates.
Ketamine hydrochloride supplier cas 1867669 tocris. Ketamine powder is a rapidacting anesthetic that can produce anesthesia while maintaining skeletal muscle tone, laryngealpharyngeal reflexes, and cardiovascular and respiratory stimulation. Heart function, breathing, and airway reflexes generally remain functional. For a listing of dosage forms and brand names by country availability, see dosage forms sections. Capillary zone electrophoresis method ketceq1 internal standard stock solution.
Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Ketamine hydrochloride drug information, professional. Ketamine hydrochloride injection may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. Ketamine hcl injection, usp veterinary injection for intramuscular use in cats and subhuman primates only caution federal law restricts this drug to use by or on the order of a licensed veterinarian. M for glun1glun2a formally nr1 and nr2a, respectively and glun1. Dec 19, 2018 zetamine ketamine hydrochloride injection is a rapidacting, nonnarcotic, nonbarbiturate agent for anesthetic use in cats and for restraint in subhuman primates. You should not receive ketamine if you are allergic to it, or if you have untreated or uncontrolled hypertension high blood pressure. Ketamine powder ketamine rationale for inclusion in pa program. Chemical product and company information manufacturer name hospira, inc. Intended use of the product use of the substancemixture.
H336 note the ingredients listed above are considered hazardous or are the active ingredient. In a published report, ketamine was clastogenic in the in vitro chromosomal aberration assay. Ketamine injection is commercially available in 10 mgml, 50 mgml and 100 mgml vials 12. Ketamine hcl is a rapidacting, nonnarcotic, nonbarbiturate agent for anesthetic use in cats and for restraint in subhuman primates. Dailymed ketamine hydrochloride injection, solution.
Composition information on ingredients ingredient cas number eu einecselincs list ghs classification % ketamine hydrochloride 1867669 2174846 acute tox. It is used to produce sleep before and during surgery. Ketamine hydrochloride injection provides 100 mgml of. Ketamine hydrochloride api manufacturers pharmacompass. Hazards identification general advice consult a physician. Ketamine hcl 100 mgml is indicated for use in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. Accurately weigh and prepare a standard solution of ketamine hydrochloride at approximately 0. Mylan manufactures ketamine hydrochloride injection, usp ketalar in strengths of 200 mg20 ml 10 mgml500 mg10 ml 50 mgml mg10 ml 100 mgml. Noncompetitive nmda receptor antagonist ec 50 values are. If inhaled if breathed in, move person into fresh air. Other uses include sedation in intensive care and treatment of pain and depression.
Other notes telephone orders are not accepted for this product. Amitriptyline hydrochloride material safety data sheet cas no. Ketamine is a cyclohexanone derivative with analgesic and anesthetic properties. Impairment of fertility adequate studies to evaluate the impact of ketamine on male or female fertility have not been conducted. And address 275 north field drive lake forest, illinois 60045 usa note. Recently, olney and coworkers have demonstrated severe widespread apoptotic degeneration throughout the rapidly developing brain of the 7dayold rat after ketamine administration. See section 16 for full text of eu and ghs classifications. Ketamine may transiently increase blood pressure and heart rate. Ketaset ketamine hydrochloride injection is supplied as the hydrochloride in concentrations equivalent to ketamine base. Ketamine hydrochloride patient information including how should i take what should i discuss with my health care provider before receiving ketamine. Name, address, and telephone of the responsible party company putney, inc. Ketamine hydrochloride injection, usp ketalar 200 mg20.
The ndealkylated amine metabolite of ketamine hcl was detected in plasma of all cats and peak levels which were 0. It induces a trancelike state while providing pain relief, sedation, and memory loss. The use of ketamine has been shown to lead to a state of. Bracketed information in the indications section refers to uses that are not included in u. Msds sds are dated when they are originally issued and when any significant change has been made to the chemical. Dailymed zetamine ketamine hydrochloride injection. Amitriptyline hydrochloride material safety data sheet. The increase in blood pressure may be up to 50% over the preanesthesia values, but usually decreases to preanesthesia values within 15 minutes of initial administration. Action ketaset is a rapidacting agent whose pharmacological action is characterized by profound analgesia, normal. Ketamine hydrochloride 1867669 2174846 120% harmful xn.
Ketamine hydrochloride injection, usp safety data sheet according to federal register vol. Composition information on ingredients ingredient cas number eu einecselincs list eu classification ghs classification % ketamine hydrochloride 1867669 2174846 xn,r22 acute tox. Ketamine increases intracranial cerebrospinal fluid pressure 51. It is a dea controlled substance schedule iii and does require dea registration. Ketamine has been reported being used as a drug of abuse, it is a dea schedule iii controlled drug substance.
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